• J Pain Palliat Care Pharmacother · Jan 2002

    Review

    What is the most effective therapy for preventing NSAID-induced gastropathy?

    • Jane Chandramouli.
    • Department of Pharmacy Services, University Hospitals and Clinics, Salt Lake City, UT 84132, USA. jane.chandramouli@hsc.utah.edu
    • J Pain Palliat Care Pharmacother. 2002 Jan 1; 16 (2): 23-36.

    AbstractNonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal toxicity is associated with morbidity and mortality, and given the very wide use of NSAIDs, is problematic and costly to society. Several options are now available to minimize gastrointestinal toxicity from NSAIDs. These options include the proton pump inhibitors, misoprostil, double-dose H2-receptor blockers and the COX-2 selective NSAIDs. No head-to-head clinical trials have compared these options. The effectiveness of these strategies to minimize NSAID-induced gastrointestinal toxicity is summarized. In addition, their associated adverse effect profiles and costs are compared.

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