• Götz Bosse, Jan-Philipp Breuer, and Claudia Spies.
• Department of Anaesthesiology, Charité Campus Mitte and Charité Campus Virchow-Klinikum, Charité-University Medicine Berlin, Schumannstrasse 20/21, 10089 Berlin, Germany.
• Best Pract Res Clin Anaesthesiol. 2006 Sep 1; 20 (3): 379-95.

AbstractBridging the gap between scientific evidence and its practical application is of the utmost importance in improving the quality of care and increasing patient safety. Guidelines based on evidenced-based medicine (EBM) have led to improved performances and better outcomes. However, even though scientific data are available, resistance to adopting evidence-based guidelines is still enormous. Significant barriers hinder the introduction of best medical practice into the daily clinical routine. The barriers to implementing change are complex, multifunctional, and influenced on many levels by various interests both inside and outside the health-care system. Political, organizational, financial, cultural and scientific interests are regarded as being as important as the perception of patients and health workers. Strategies need to be planned which take account of the multidimensional character of quality of care and incorporate it at the various levels. The conclusion, therefore, is that we need to combine methods and tools to tailor our interventions to the patient's needs.

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