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Best Pract Res Clin Anaesthesiol · Jun 2007
The impact of storage on red cell function in blood transfusion.
- Emre Almac and Can Ince.
- Clinical Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
- Best Pract Res Clin Anaesthesiol. 2007 Jun 1; 21 (2): 195-208.
AbstractDespite the common use of red-blood-cell transfusions in clinical practice, actual beneficial effects of red blood cells have never been demonstrated. On the contrary, several studies suggest that red-blood-cell transfusions are associated with higher risks of morbidity and mortality. The effects of the duration of storage on the efficacy of red blood cells have therefore been questioned in a number of studies. Recent insights into the physiology of red blood cells such as the role of the hypoxia-induced vasodilator-releasing function of red blood cells--is discussed in relation to the controversy surrounding the use of blood transfusions in clinical practice.
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