• Best Pract Res Clin Anaesthesiol · Jun 2008

    Review

    Physiology and pathophysiology of the vasopressinergic system.

    • Jean-Louis Vincent and Fuhong Su.
    • Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium. jlvincen@ulb.ac.be
    • Best Pract Res Clin Anaesthesiol. 2008 Jun 1; 22 (2): 243-52.

    AbstractArginine vasopressin, a hypothalamic peptide hormone, has multiple physiological functions, including body water regulation, control of blood pressure and effects on body temperature, insulin release, corticotropin release, memory and social behaviour. These functions are achieved via at least three specific G-protein-coupled vasopressin receptors. Development of specific vasopressin receptor antagonists in recent years is helping to elucidate the precise actions of vasopressin at each of these receptor types. The complex signalling and messenger processes which take place after receptor stimulation are now more clearly understood. Vasopressin dysregulation can occur in various disease processes, and a better understanding of the mechanisms underlying physiological synthesis, release and regulation of vasopressin will help in the development of therapies to treat these conditions.

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