• Bruno Splavski, Krešimir Rotim, Frederick A Boop, Andrew J Gienapp, and Kenan I Arnautović.
• Department of Neurosurgery, Sisters of Mercy University Hospital Center, Zagreb, Croatia; Osijek University School of Medicine, Osijek, Croatia; Osijek University School of Dental Medicine and Health, Osijek, Croatia.
• World Neurosurg. 2020 Feb 1; 134: 233-239.

AbstractAmbroise Paré was celebrated surgeon of the 16th century whose practical accomplishments, books, and ideas transformed surgery and was a precursor for the later development of neurosurgery. He developed many surgical innovations related to wound management, arterial ligation for the prevention of hemorrhage during limb amputations, and the treatment of war-related head and spine injuries. He maintained that a surgeon should operate gently to reduce pain and improve outcome, and he dedicated his career to the wounded, sick, and poor. He also served 4 consecutive French monarchs-Henri II and his 3 sons François II, Charles IX, and Henri III. As a Huguenot (a Reformed Protestant) by faith, he lived in an environment dominated by Catholicism. Hence, his practice and life were sometimes hindered by political circumstances and religious prejudice. In this historical vignette, we will discuss the professional accomplishments of Ambroise Paré that influenced the future development of neurosurgery, including his descriptions of phantom-limb pain and peripheral nerve injury, his innovations in neurotraumatology, and the saws he invented for use in skull surgery. We will also highlight Paré's broad neurosurgical contributions to the field. Finally, we will discuss his personal life during the difficult and dangerous political circumstances of 16th century France.Copyright © 2019 Elsevier Inc. All rights reserved.

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