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Review Case Reports
Transformation of grade II to grade III rhabdoid-papillary meningioma: Is SRS the culprit? A case report and literature review.
- Ioannis Christodoulides, José Pedro Lavrador, Istvan Bodi, Ross Laxton, Richard Gullan, Ranjeev Bhangoo, Francesco Vergani, and Keyoumars Ashkan.
- Department of Neurosurgery, King's College Hospital Foundation Trust, London, United Kingdom. Electronic address: ychristodoulides@gmail.com.
- World Neurosurg. 2020 Feb 1; 134: 337-342.
BackgroundIn the management of meningiomas, single-fraction stereotactic radiosurgery (SRS) is an established alternative treatment to surgical resection. However, its effects on tumorigenesis and malignant transformation are still uncertain.Case DescriptionWe have described a grade II parafalcine meningioma that was initially surgically resected (Simpson 2 clearance) and then managed with a single dose of SRS on recurrence. The tumor recurred again 7 years later, with histological features of a grade III rhabdoid-papillary lesion, with local brain invasion.ConclusionTo the best of our knowledge, this is the first report to describe malignant transformation of a grade II to grade III meningioma after SRS to date.Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved.
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