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- Tomoko Takahashi, Kazumasa Okubo, Shota Kojima, Hiroyuki Nishikawa, Motohide Takemura, Maho Tsubota-Matsunami, Fumiko Sekiguchi, and Atsufumi Kawabata.
- Division of Pharmacology & Pathophysiology, Kinki University School of Pharmacy, Japan.
- J. Pharmacol. Sci. 2013 Jan 1; 122 (1): 51-4.
AbstractWe evaluated the effect of buprenorphine, a mixed agonist for μ-opioid receptors and nociceptin/orphanin FQ peptide (NOP) receptors, in neuropathic rats, using the paw pressure test. Buprenorphine, administered i.p. at 50, but not 20, μg/kg, exhibited naloxone-reversible analgesic activity in naïve rats. In contrast, buprenorphine at 0.5 - 20 μg/kg produced a naloxonesensitive antihyperalgesic effect in the L5 spinal nerve-injured neuropathic rats. Intrathecal injection of [N-Phe(1)]nociceptin(1-13)NH2, a NOP-receptor antagonist, reversed the effect of buprenorphine in neuropathic rats, but not in naïve rats. Together, buprenorphine suppresses neuropathic hyperalgesia by activating NOP and opioid receptors, suggesting its therapeutic usefulness in treatment of neuropathic pain.
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