• Curr Pain Headache Rep · Oct 2008

    Review

    Fibromyalgia: an update and immunological aspects.

    • Eduardo S Paiva, Evelin Diana Goldenberg Mariano da Costa, and Morton Scheinberg.
    • Hospital Israelita, Albert Einstein and Research Institute, Av. Albert Einstein 627, Sao Paulo, Brazil.
    • Curr Pain Headache Rep. 2008 Oct 1; 12 (5): 321-6.

    AbstractFibromyalgia syndrome (FMS) is now understood as a chronic pain syndrome, and recent evidence indicates it is not a pure psychosomatic disorder. We review the current knowledge in FMS pain pathways, focusing on the central system sensitization phenomenon and the abnormalities in the inhibitory pain systems. Chronic headache is one of the most common symptoms in FMS, and better knowledge of their common pathophysiologic features can help us understand both conditions better. These features include the nerve growth factor actions and failure of the endocannabinoid system. In addition, we review new immunological aspects of FMS, both in their humoral (autoantibodies, antipolymer antibodies) and cytokine (interleukin-2) aspects.

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