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Curr Pain Headache Rep · Jun 2006
ReviewInsights from experimental studies into allodynia and its treatment.
- Michael L Oshinsky.
- Department of Neurology, Thomas Jefferson University, 1020 Locust Street, Suite 398 JAH, Philadelphia, PA 19107, USA. michael.oshinsky@jefferson.edu
- Curr Pain Headache Rep. 2006 Jun 1; 10 (3): 225-30.
AbstractMigraine is a common disorder that often is accompanied by cutaneous allodynia. Cutaneous allodynia on the head has been linked to sensitization of neurons in the trigeminal nucleus caudalis in animal models of migraine. In addition, migraine with allodynia is refractory to acute treatment with triptans. Understanding the mechanisms of allodynia, preventing its development, and finding effective treatments have become a priority in headache research. This paper reviews recent research on the pathogenesis of headache and the generation of allodynia. We discuss the regions of the nervous system that are involved in generating and maintaining headache pain and allodynia. We also discuss recent advances in the treatment of migraine based on translation research.
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