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Curr Pain Headache Rep · Jun 2008
ReviewPathophysiology and treatment of painful diabetic neuropathy.
- Mitra Tavakoli, Moaz Mojaddidi, Hassan Fadavi, and Rayaz A Malik.
- Division of Cardiovascular Medicine, University of Manchester, Manchester, UK.
- Curr Pain Headache Rep. 2008 Jun 1; 12 (3): 192-7.
AbstractDiabetes is the most common cause of peripheral neuropathy, and painful diabetic neuropathy (PDN) affects approximately 30% of diabetic patients with neuropathy. It is extremely distressing for the patient and poses significant management difficulties because no treatment provides total relief, and side effects of therapy are a major limiting factor for titrating therapy. Understanding the pathogenesis of diabetic neuropathy may lead to the development of new treatments to prevent nerve damage, and a better understanding of the mechanisms that modulate pain may lead to more effective relief of painful symptoms. We provide an update on the pathogenesis, diagnosis, and treatment of PDN.
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