• Curr Pain Headache Rep · Dec 2008

    Review

    Pragmatic consideration of recent randomized, placebo-controlled clinical trials for treatment of fibromyalgia.

    • Andrew J Holman.
    • Pacific Rheumatology Research, Renton, WA 98055, USA. AJHSeattle@aol.com
    • Curr Pain Headache Rep. 2008 Dec 1; 12 (6): 393-8.

    AbstractA flurry of recent randomized, placebo-controlled trials assessing dissimilar pharmacotherapeutic treatment options for fibromyalgia (FM) have been presented in the past few years. This review evaluates these trials in light of recent pathophysiological concepts germane to FM, including mood disorders, autonomic dysregulation, altered sleep stage architecture, and the diagnostic tender point controversy. Studies with gabapentin, pregabalin, duloxetine, milnacipran, sodium oxybate, and pramipexole for treatment of FM are discussed.

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