• Curr Pain Headache Rep · Oct 2009

    Review

    The associations between migraine, unipolar psychiatric comorbidities, and stress-related disorders and the role of estrogen.

    • B Lee Peterlin, Michael J Katsnelson, and Anne H Calhoun.
    • Drexel University College of Medicine, 245 North 15th Street, MS 423, Philadelphia, PA 19102, USA. lee.peterlin@drexelmed.edu
    • Curr Pain Headache Rep. 2009 Oct 1; 13 (5): 404412404-12.

    AbstractMigraine is a common and often disabling neurovascular disorder. It has been linked with several psychiatric disorders, such as depression and anxiety, and to stress-related disorders, such as abuse and posttraumatic stress disorder (PTSD). Epidemiological data have consistently shown a higher prevalence of migraine, depression, anxiety, abuse, and PTSD in women as compared with men. The increased vulnerability of women to migraine and psychiatric disorders often occurs during periods of marked hormonal fluctuations of ovarian hormones. One consequence of these associations is the hypothesis that estrogens have a role in the pathophysiology of both disorders. This article offers an in-depth review of several studies linking psychiatric disorders and stress-related disorders with migraine. We also discuss the role of estrogen in the pathophysiologic overlap between these disorders. Finally, we briefly touch on where future research may be headed, in light of these data.

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