• Clinical case reports · Oct 2013

    Reversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation.

    • Matthew R Lewin, Philip Bickler, Tom Heier, John Feiner, Lance Montauk, and Brett Mensh.
    • Center for Exploration and Travel Health, California Academy of Sciences San Francisco, California, USA.
    • Clin Case Rep. 2013 Oct 1; 1 (1): 7-15.

    Key Clinical MessageNeurotoxic snake envenomation can result in respiratory failure and death. Early treatment is considered important to survival. Inexpensive, heat-stable, needle-free, antiparalytics could facilitate early treatment of snakebite and save lives, but none have been developed. An experiment using aerosolized neostigmine to reverse paralysis suggests how early interventions could be developed.

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