• Karl H Stadlbauer, Volker Wenzel, Horst G Wagner-Berger, Anette C Krismer, Alfred Königsrainer, Wolfgang G Voelckel, Claus Raedler, Christian A Schmittinger, Karl H Lindner, and Guenter Klima.
• Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria. karl-heinz.stadlbauer@uibk.ac.at
• Resuscitation. 2007 Jan 1; 72 (1): 145-8.

AbstractThe effects of vasopressin on the gut in a porcine uncontrolled haemorrhagic shock model are described. In eight anaesthetised pigs, a liver laceration was performed; when haemorrhagic shock was decompensated, all animals received 0.4 IU/kg vasopressin, followed by 0.08 IU/kg min over 30 min, which maintained a mean arterial blood pressure >40 mmHg. Subsequent surgical intervention, infusion of whole blood and fluids resulted in a stable cardiocirculatory status. Three hours after stabilisation, all pigs developed non-bloody diarrhoea which converted into normal bowel movements within 24 h. All histological samples retained 7 days after the experiment revealed no histopathological changes. In conclusion, in this small observational study of uncontrolled porcine haemorrhagic shock, a resuscitation strategy that included high dose vasopressin was associated with transient diarrhoea and good long term survival.

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