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Critical care medicine · Nov 1983
Spontaneous ischemic ventricular fibrillation in dogs: a new model for the study of cardiopulmonary resuscitation.
- C W Otto, R W Yakaitis, and G A Ewy.
- Crit. Care Med. 1983 Nov 1; 11 (11): 883-7.
AbstractMost sudden cardiac deaths in man are associated with events causing myocardial ischemia and only 40-60% of these patients are successfully resuscitated. Further progress in reducing the mortality from such events will depend on a better understanding of the interventions used during CPR. Animal models currently used for the study of CPR do not involve myocardial ischemia. A new model of cardiac arrest (spontaneous ischemic ventricular fibrillation) in closed-chest dogs resembles more closely the events occurring in man. Initial controlled, randomized studies of the model demonstrate that it responds to resuscitation in a manner similar to human resuscitation. Further study of this model during CPR may lead to changes in patient care which will improve survival from episodes of sudden cardiac death.
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