• Critical care clinics · Jan 2020

    Review

    Metabolomics and the Microbiome as Biomarkers in Sepsis.

    • Jisoo Lee and Debasree Banerjee.
    • Division of Pulmonary, Critical Care and Sleep Medicine, The Warren Alpert School of Medicine at Brown University, Providence, RI, USA; Division of Pulmonary, Critical Care & Sleep Medicine, Rhode Island Hospital, POB Suite 224, 595 Eddy Street, Providence, RI 02903, USA. Electronic address: jisoo_lee@brown.edu.
    • Crit Care Clin. 2020 Jan 1; 36 (1): 105-113.

    AbstractMetabolomics is an emerging field of research interest in sepsis. Metabolomics provides new ways of exploring the diagnosis, mechanism, and prognosis of sepsis. Advancements in technologies have enabled significant improvements in identifying novel biomarkers associated with the disease progress of sepsis. The use of metabolomics in the critically ill may provide new approaches to enable precision medicine. Furthermore, the dynamic interactions of the host and its microbiome can lead to further progression of sepsis. Understanding these interactions and the changes in the host's genomics and the microbiome can provide novel preventive and therapeutic strategies against sepsis.Copyright © 2019 Elsevier Inc. All rights reserved.

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