• Critical care clinics · Jan 2020

    Review

    Biomarkers of Infection and Sepsis.

    • Steven M Opal and Xavier Wittebole.
    • Infectious Disease Division, Alpert Medical School of Brown University, Ocean State Clinical Coordinating Center at Rhode Island Hospital, 1 Virginia Avenue Suite 105, Providence, RI 02905, USA. Electronic address: Steven_Opal@brown.edu.
    • Crit Care Clin. 2020 Jan 1; 36 (1): 11-22.

    AbstractThe role of biomarkers for detection of sepsis has come a long way. Molecular biomarkers are taking front stage at present, but machine learning and other computational measures using bigdata sets are promising. Clinical research in sepsis is hampered by lack of specificity of the diagnosis; sepsis is a syndrome with no uniformly agreed definition. This lack of diagnostic precision means there is no gold standard for this diagnosis. The final conclusion is expert opinion, which is not bad but not perfect. Perhaps machine learning will displace expert opinion as the final and most accurate definition for sepsis.Copyright © 2019 Elsevier Inc. All rights reserved.

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