• Wytske Geense, Marieke Zegers, Peter Dieperink, Hester Vermeulen, Johannes van der Hoeven, and Mark van den Boogaard.
• Department of Intensive Care Medicine, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: wytske.geense@radboudumc.nl.
• J Crit Care. 2020 Feb 1; 55: 184-193.

PurposeFrailty is an important predictor for the prognosis of intensive care unit (ICU) patients. This study examined changes in frailty in the year after ICU admission, and its associated factors.Materials And MethodsProspective cohort study including adult ICU patients admitted between July 2016-December 2017. Frailty was measured using the Clinical Frailty Scale (CFS), before ICU admission, at hospital discharge, and three and 12 months after ICU admission. Multivariable linear regression was used to explore factors associated with frailty changes.ResultsFrailty levels changed among 1300 ICU survivors, with higher levels at hospital discharge and lower levels in the following months. After one year were 42% of the unplanned, and 27% of the planned patients more frail. For both groups were older age, longer hospital length of stay, and discharge location associated with being more frail. Male sex, higher education level and mechanical ventilation were associated with being less frail in the planned patients.ConclusionOne year after ICU admission, 42% and 27% of the unplanned and planned ICU patients, respectively, were more frail. Insight in the associated factors will help to identify patients at risk, and may help in informing patients and their family members.RegistrationClinicalTrials.gov database (NCT03246334).Copyright © 2019 Elsevier Inc. All rights reserved.

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