• J Cardiovasc Med (Hagerstown) · Oct 2011

    Review Case Reports

    Isolated creatine kinase-MB rise with normal cardiac troponins: a strange occurrence with difficult interpretation.

    • Fabrizio Ricci and Raffaele De Caterina.
    • Institute of Cardiology, G. d'Annunzio University, Chieti, Italy.
    • J Cardiovasc Med (Hagerstown). 2011 Oct 1; 12 (10): 736-40.

    AbstractA 37-year-old man is admitted to the hospital for retrosternal chest pain lasting more than 30  min and nonspecific ECG findings. Serial assays of cardiac biomarkers reveal an isolated elevation of creatine kinase-MB and negative troponin levels. A coronary angiography shows normal vessels in the presence of a Thrombolysis in Myocardial Infarction (TIMI) 2 flow. How should this patient be managed and treated? Is it a myocardial infarction? We here provide a review of the relevant literature and suggest that such a strange condition, for which several explanations are possible, involves a worse prognosis than for normal creatine kinase-MB and troponins.

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