• World Neurosurg · Feb 2020

    Review Case Reports

    Purely Meningeal Intracranial Relapse of Melanoma Brain Metastases after Surgical Resection and Immunotherapy as a Unique Disease Progression pattern: Our Experience and Review of the Literature.

    • Daniele Armocida, Francesco Marzetti, Alessandro Pesce, Alessandro Caporlingua, Luca D'Angelo, and Antonio Santoro.
    • Azienda Ospedaliero-Universitaria "Policlinico Umberto I", Neurosurgery Division, Human Neurosciences Department, Sapienza University, Rome, Italy. Electronic address: danielearmocida@yahoo.it.
    • World Neurosurg. 2020 Feb 1; 134: 150154150-154.

    BackgroundWe present a case of 72-year-old man with a history of metastatic melanoma diagnosed in 2015 presenting a stable disease in treatment with dabrafenib.Case DescriptionThe patient had been surgically treated for a presumed intracranial parietooccipital metastasis. He presented 1 month later with a meningeal lesion associated with a subdural hematoma. A second surgical treatment confirmed the diagnosis of meningeal recurrence of metastatic melanoma.ConclusionsThe most recent literature lacks studies defining the clinical phenomena of an early recurrence of intracranial melanoma with de novo involvement of dural compartment in patients in treatment with a target immunotherapy. The aim of this present study is to report a case of early recurrence of intracranial melanoma metastases with evidence of fast immunohistochemical and macroscopical mutation of pathologic elements, with an analysis of literature that shows the lack of well-described occurrences.Copyright © 2019 Elsevier Inc. All rights reserved.

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