• Spine · May 2020

    Transcriptome-Wide Sequencing Reveals Molecules and Pathways Involved in Neurofibromatosis Type I Combined with Spinal Deformities.

    • Siyi Cai, Yuemei Yang, Binghan Jia, Zhihong Wu, Jianguo Zhang, Jianxiong Shen, and Guixing Qiu.
    • Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
    • Spine. 2020 May 1; 45 (9): E489-E498.

    AbstractMINI: We identified differentially expressed genes (DEGs) that may be involved in the development of neurofibromatosis type I by whole-transcriptional sequencing. Seven hundred eighty DEGs were identified which include protein coding genes, miRNAs, and lncRNAs. The enrichment analysis may reveal pathways that these DEGs involved. A total of 383 protein-pairs for DEGs may unfold the possible mechanism how the disease is developed.

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