• Spine · May 2020

    Circulating miR-155-5p as a Novel Biomarker of Lumbar Degenerative Disc Disease.

    • Srikanth N Divi, Dessislava Z Markova, Taolin Fang, Ryan Guzek, Mark F Kurd, Jeffrey A Rihn, Alan S Hilibrand, David Greg Anderson, Alexander R Vaccaro, Gregory D Schroeder, and Christopher K Kepler.
    • Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA.
    • Spine. 2020 May 1; 45 (9): E499-E507.

    AbstractMINI: Circulating microRNAs provide an insight into current disease states. Comparing patients with degenerative disc disease to healthy controls, patients with disc disease were found to have significantly downregulated levels of miR-155-5p. This marker was found to be an accurate diagnostic predictor for the presence of degeneration (P = 0.006).

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