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Critical care medicine · May 1986
Case ReportsUse of ketamine in asthmatic children to treat respiratory failure refractory to conventional therapy.
- M J Rock, S Reyes de la Rocha, C S L'Hommedieu, and E Truemper.
- Crit. Care Med. 1986 May 1; 14 (5): 514-6.
AbstractWe treated two pediatric patients suffering respiratory failure associated with status asthmaticus. Neither patient responded to maximal bronchodilatory therapy and mechanical ventilation; however, continuous infusion of ketamine (1.0 to 2.5 mg/kg X h) immediately improved airway obstruction. Ketamine appears to increase catecholamine levels and directly relax bronchial smooth muscle. Except for increased secretions during the infusion, our patients showed no immediate or long-term sequelae from ketamine therapy. However, ketamine should only be used for asthmatics whose respiratory failure does not respond to conventional management and mechanical ventilation.
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