• Langenbecks Arch Chir Suppl Kongressbd · Jan 1998

    [Tumor necrosis factor-alpha (TNF-alpha) gene polymorphism in surgical intensive care patients with SIRS].

    • K Dumon, C Rossbach, B Harms, V Gorelov, W Gross-Weege, E M Schneider, P E Goretzki, and H D Röher.
    • Klinik für Allgemein- und Unfallchirurgie, Heinrich-Heine Universität, Moorenstrasse 5, 40225 Düsseldorf.
    • Langenbecks Arch Chir Suppl Kongressbd. 1998 Jan 1; 115 (Suppl I): 387-90.

    AbstractBiallelic polymorphism in the promotor region of the TNF-alpha gene have been associated with variation in TNF-alpha production. We determined the TNFA polymorphism (position--308) and related these data to plasma cytokine levels of TNF alpha, IL6, IL6R and IL8 in patients with SIRS and sepsis. Although there seems to be a different cytokine secretion pattern for both allelic groups (TNFA1 and TNFA2), a clear risk group could not be determined. It still remains unclear whether there is a genetic factor that influences the development of sepsis and multi organ failure.

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