• Nat Rev Clin Oncol · Sep 2014

    Targeted therapies: redefining the primary objective of phase I oncology trials.

    • Mark J Ratain.
    • Department of Medicine, Comprehensive Cancer Center, and Center for Personalized Therapeutics, The University of Chicago, 5841 South Maryland Avenue, MC2115, Chicago, IL 60637, USA.
    • Nat Rev Clin Oncol. 2014 Sep 1; 11 (9): 503-4.

    AbstractCytotoxic agents are conventionally dosed on the basis of the maximum tolerated dose defined in phase I trials. A study assessing adverse events in over 2,000 patients treated with molecularly targeted agents suggests a need to redefine criteria for dosing of molecularly targeted agents, which should be based on randomized, dose-ranging phase II trials.

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