• Yumiko Oishi Department of Neurosurgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan., Ryota Tamura, Satoshi Takahashi, Yukina Morimoto, Mizuto Sato, Tomo Horikoshi, Shady Hassaan, Kazunari Yoshida, and Masahiro Toda.
• Department of Neurosurgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
• World Neurosurg. 2020 Feb 1; 134: e1099-e1107.

BackgroundSkull base chordomas (SBCs) are rare clinically aggressive neoplasms, developing local recurrences after surgical resection. Although SBCs have traditionally been resected by craniotomy or microscopic transsphenoidal surgery (TSS), the recent development of the endoscopic endonasal approach (EEA) has revolutionized treatment strategies through minimally invasive techniques. This study aimed to evaluate clinical outcomes after traditional microsurgeries or EEAs for SBCs.MethodsThe present retrospective study investigated 66 patients with primary SBCs who underwent surgery between 1977 and 2019. Resection was performed via EEA in 17 cases, craniotomy in 23, transoral approach in 8, TSS in 12, staged surgery in 4, and others in 2. The median follow-up period for progression-free survival (PFS) was 19.5 months.ResultsThere were no significant differences in preoperative tumor volume or resection rate among these approaches. The incidence of postoperative cranial nerve palsy was significantly lower in EEA than that in craniotomy (P < 0.05). Although total resection was observed in 4 cases of EEA expanding into the superior and inferior part of the clivus, no cases of transoral approach or TSS achieved total resection for both parts. No significant difference in PFS was found among these approaches. Multivariate analysis showed that being female and the absence of radiotherapy were significantly associated with shorter PFS (P < 0.05 and P < 0.001, respectively). The resection rate was not associated with PFS.ConclusionsEEA is a less invasive surgical approach for SBCs. The development of surgical instruments and postoperative radiotherapy will further improve patients' outcomes.Copyright © 2019 Elsevier Inc. All rights reserved.

37 keywords...

hide…