• Crit Care · Dec 2019

    Observational Study

    Ultrasound-based clinical profiles for predicting the risk of intradialytic hypotension in critically ill patients on intermittent dialysis: a prospective observational study.

    • Rogerio da Hora Passos, Juliana Caldas, Ramos Joao Gabriel Rosa JGR Critical Care Unit, Hospital São Rafael, Salvador, Bahia, Brazil., Erica Batista Dos Santos Galvão de Melo, Michel Por Deus Ribeiro, Maria Fernanda Coelho Alves, Batista Paulo Benigno Pena PBP Critical Care Unit and Nephrology Department, Hospital São Rafael, Salvador, Bahia, Brazil., Messeder Octavio Henrique Coelho OHC Critical Care Unit, Hospital Português, Salvador, Bahia, Brazil., Augusto Manoel de Carvalho de Farias, Etienne Macedo, and Jean Jacques Rouby.
    • Critical Care Unit and Nephrology Department, Hospital Português and Hospital São Rafael, Salvador, Bahia, Brazil. oiregorpassos@yahoo.com.br.
    • Crit Care. 2019 Dec 2; 23 (1): 389.

    BackgroundIntradialytic hypotension, a complication of intermittent hemodialysis, decreases the efficacy of dialysis and increases long-term mortality. This study was aimed to determine whether different predialysis ultrasound cardiopulmonary profiles could predict intradialytic hypotension.MethodsThis prospective observational single-center study was performed in 248 critically ill patients with acute kidney injury undergoing intermittent hemodialysis. Immediately before hemodialysis, vena cava collapsibility was measured by vena cava ultrasound and pulmonary congestion by lung ultrasound. Factors predicting intradialytic hypotension were identified by multiple logistic regression analysis.ResultsIntradialytic hypotension was observed in 31.9% (n = 79) of the patients, interruption of dialysis because of intradialytic hypotension occurred in 6.8% (n = 31) of the sessions, and overall 28-day mortality was 20.1% (n = 50). Patients were classified in four ultrasound profiles: (A) 108 with B lines > 14 and vena cava collapsibility > 11.5 mm m-2, (B) 38 with B lines < 14 and vena cava collapsibility ≤ 11.5 mm m-2, (C) 36 with B lines > 14 and vena cava collapsibility Di ≤ 11.5 mm m-2, and (D) 66 with B lines < 14 and vena cava collapsibility > 11.5 mm m-2. There was an increased risk of intradialytic hypotension in patients receiving norepinephrine (odds ratios = 15, p = 0.001) and with profiles B (odds ratios = 12, p = 0.001) and C (odds ratios = 17, p = 0.001).ConclusionIn critically ill patients on intermittent hemodialysis, the absence of hypervolemia as assessed by lung and vena cava ultrasound predisposes to intradialytic hypotension and suggests alternative techniques of hemodialysis to provide better hemodynamic stability.

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