• Arthur Kwizera, Niranjan Kissoon, Ndidiamaka Musa, Olivier Urayeneza, Pierre Mujyarugamba, Andrew J Patterson, Lori Harmon, Joseph C Farmer, Martin W Dünser, Jens Meier, and “Sepsis in Resource-Limited Nations” Task Force of the Surviving Sepsis Campaign.
• Department of Anaesthesia and Critical Care, Makerere University College of Health Sciences, Kampala, Uganda.
• Pediatr Crit Care Me. 2019 Dec 1; 20 (12): e524-e530.

ObjectivesTo deploy machine learning tools (random forests) to develop a model that reliably predicts hospital mortality in children with acute infections residing in low- and middle-income countries, using age and other variables collected at hospital admission.DesignPost hoc analysis of a single-center, prospective, before-and-after feasibility trial.SettingRural district hospital in Rwanda, a low-income country in Sub-Sahara Africa.PatientsInfants and children greater than 28 days and less than 18 years of life hospitalized because of an acute infection.InterventionsNone.Measurements And Main ResultsAge, vital signs (heart rate, respiratory rate, and temperature) capillary refill time, altered mental state collected at hospital admission, as well as survival status at hospital discharge were extracted from the trial database. This information was collected for 1,579 adult and pediatric patients admitted to a regional referral hospital with an acute infection in rural Rwanda. Nine-hundred forty-nine children were included in this analysis. We predicted survival in study subjects using random forests, a machine learning algorithm. Five prediction models, all including age plus two to five other variables, were tested. Three distinct optimization criteria of the algorithm were then compared. The in-hospital mortality was 1.5% (n = 14). All five models could predict in-hospital mortality with an area under the receiver operating characteristic curve ranging between 0.69 and 0.8. The model including age, respiratory rate, capillary refill time, altered mental state exhibited the highest predictive value area under the receiver operating characteristic curve 0.8 (95% CI, 0.78-0.8) with the lowest possible number of variables.ConclusionsA machine learning-based algorithm could reliably predict hospital mortality in a Sub-Sahara African population of 949 children with an acute infection using easily collected information at admission which includes age, respiratory rate, capillary refill time, and altered mental state. Future studies need to evaluate and strengthen this algorithm in larger pediatric populations, both in high- and low-/middle-income countries.

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