• World Neurosurg · Mar 2020

    Case Reports

    SHH-activated Large cell/Anaplastic medulloblastoma with myogenic differentiation - case report.

    • Shilpa Rao, Uppar Alok Mohan AM Departments of Neuropathology and Neurosurgery, National Institute of Mental Health and Neurosciences, Bangladore, India., and Vani Santosh.
    • Departments of Neuropathology and Neurosurgery, National Institute of Mental Health and Neurosciences, Bangladore, India.
    • World Neurosurg. 2020 Mar 1; 135: 16-18.

    BackgroundMedulloblastoma (MB) with myogenic differentiation is a rare histologic variant.Case DescriptionWe report a case of a 7-year-old female child who presented with a left cerebellar mass. Histopathologic examination showed a cellular neoplasm comprising undifferentiated cells along with foci of bizarre giant cells. Immunohistochemistry revealed that the tumor corresponded to the MB, sonic hedgehog-activated subgroup.ConclusionsThe case is being reported to document this rare variant of MB that had myogenic differentiation. Molecular characterization of this variant has been analyzed in few cases so far.Copyright © 2019 Elsevier Inc. All rights reserved.

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