• Pediatric emergency care · Dec 2021

    Electrocardiographic Changes in Children With Acute Opioid Poisoning: A Cross-Sectional Study.

    • Hamidreza Riasi, Navid Rabiee, Tayebeh Chahkandi, Forough Arzanin, Siavash Kafian Atary, and Forod Salehi.
    • From the Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
    • Pediatr Emerg Care. 2021 Dec 1; 37 (12): e1082e1086e1082-e1086.

    ObjectivesOpioid poisoning in children is a common pediatric emergency in Iran. The emergence and spread of new synthetic opioids have come up with new consequences in case of toxicity. In this study, we aimed to evaluate electrocardiographic changes in children with acute opiate poisoning.MethodsThis cross-sectional study was performed on all children with opioid poisoning admitted to the emergency ward of Vali-e-Asr Hospital, Birjand, Iran, from December 2015 to February 2017. Data (demographics, manifestations, clinical course, and outcome) were collected using a predesigned checklist. An electrocardiogram (ECG) was obtained and evaluated for arrhythmias, corrected QT interval (QTc), and other ECG indices. Data were analyzed using SPSS version 21. A value of P less than 0.05 was considered statistically significant.ResultsA total of 85 children were enrolled in this study. Most of them were male (51.8%). The mean age of the patients was 3.46 ± 3.36 years. Among these children, 38.8% were poisoned with synthetic opioids (methadone). Mean QTc length was 399 ± 24 milliseconds in nonsynthetic opioid poisoning and 407 ± 66 milliseconds in methadone poisoning, and it was prolonged (>450 milliseconds) in 3.5% of cases. Other ECG changes were limited to 1 U wave formation (1.2%) that was detected in a patient with methadone poisoning.ConclusionsElectrocardiogram changes due to acute opioid toxicity in children are not common, although in the case of methadone poisoning, long QT interval and associated arrhythmias should be anticipated. Moreover, because of life-threatening effects of opioids such as respiratory insufficiency and decreased consciousness, it is necessary to be prepared for these conditions.Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

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