• Ayman El-Menyar, Abhishek Goyal, Rifat Latifi, Hassan Al-Thani, and William Frishman.
• From the *Department of Surgery, Clinical Research, Westchester Medical Center, Valhalla, NY; †Clinical Medicine, Weill Cornell Medical College, Doha, Qatar; ‡Department of Medicine, New York Medical College/Westchester Medical Center, Valhalla, NY; §Department of Surgery, New York Medical College/Westchester Medical Center, Valhalla, NY; and ¶Department of Surgery, Trauma & Vascular Surgery, Hamad General Hospital, Qatar.
• Cardiol Rev. 2017 Nov 1; 25 (6): 279-288.

AbstractThe cardiovascular manifestations associated with nontraumatic head disorders are commonly known. Similar manifestations have been reported in patients with traumatic brain injury (TBI); however, the underlying mechanisms and impact on the patient's clinical outcomes are not well explored. The neurocardiac axis theory and neurogenic stunned myocardium phenomenon could partly explain the brain-heart link and interactions and can thus pave the way to a better understanding and management of TBI. Several observational retrospective studies have shown a promising role for beta-adrenergic blockers in patients with TBI in reducing the overall TBI-related mortality. However, several questions remain to be answered in clinical randomized-controlled trials, including population selection, beta blocker type, dosage, timing, and duration of therapy, while maintaining the optimal mean arterial pressure and cerebral perfusion pressure in patients with TBI.

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