• Fei Li, Min Peng, Lei Jiang, Qi Sun, Kui Zhang, Fuzhi Lian, Augusto A Litonjua, Jinming Gao, and Xiang Gao.
• Department of Respiratory Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
• Respiration. 2011 Jan 1; 81 (6): 469-75.

BackgroundVitamin D deficiency has been associated with markers for allergy and asthma severity in children with asthma. However, its association with Chinese adult asthmatics has not been studied.ObjectiveTo examine whether vitamin D status is associated with lung function and total serum IgE in Chinese adults with newly diagnosed asthma.MethodsWe conducted a cross-sectional study including 435 Chinese patients aged >18 years with newly diagnosed asthma. Vitamin D status was assessed by measuring serum 25 hydroxyvitamin D (25OHD) concentrations. The primary outcomes included airflow limitation, as measured by the forced expiratory volume in 1 s (FEV(1)), FEV(1) % predicted, and FEV(1)/forced vital capacity (FVC), and serum total IgE concentration.ResultsVitamin D deficiency was prevalent in Chinese adults with asthma, with 88.9% of the subjects having 25OHD <50 nmol/l. Serum 25OHD concentration was positively correlated with FEV(1) % predicted (p = 0.02, r = 0.12). After adjusting for age, sex, body mass index, smoking, month of blood collection, and symptom duration, we found significant positive associations between 25OHD concentrations and FEV(1) (in liters), FEV(1) % predicted, and FEV(1)/FVC (p for trend < 0.05 for all). The adjusted odds ratios for the highest versus the lowest 25OHD quartile were 0.50 (0.26-0.96) for FEV(1) <75% predicted and 0.44 (0.20-0.95) for FEV(1)/FVC% <0.75. There was no significant association between 25OHD concentrations and total IgE.ConclusionsVitamin D deficiency was highly prevalent in Chinese asthma patients, and vitamin D status was associated with lung function.Copyright © 2010 S. Karger AG, Basel.

28 keywords...

hide…