• Rev Med Interne · Sep 2009

    Case Reports Comparative Study

    [Colchicine intoxication in four elderly patients: how to prevent it?].

    • M-L Le Bellec, B de la Gastine, B Mosquet, F Godde, R Ze Bekolo, R Gloro, C Leterrier, and A Coquerel.
    • Centre régional de pharmacovigilance, CHU Côte-de-Nacre, avenue de la Côte-de-Nacre, BP 95182, 14033 Caen cedex 9, France.
    • Rev Med Interne. 2009 Sep 1; 30 (9): 783-8.

    IntroductionIn France, unlike other countries, the use of colchicine is preferred to other anti-inflammatory drugs for the treatment of gout.Case ReportsWe report a case series of four elderly patients (range from 72 to 83 years of age) who presented with colchicine intoxication, all notified to the Basse-Normandie pharmacovigilance centre in 2007. For each patient, one or more risk factors were identified: renal failure, high initial dosage, absence of laboratory monitoring.ConclusionIt would be useful to establish specific guidelines for colchicine use in the elderly population.

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