• Kyu-Sun Choi, Kim Hyun Jung HJ Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea., Hyoung-Joon Chun, Jae Min Kim, Hyeong-Joong Yi, Jin-Hwan Cheong, Choong-Hyun Kim, Suck-Jun Oh, Yong Ko, Young-Soo Kim, Koang-Hum Bak, Je-Il Ryu, Wonhee Kim, Taeho Lim, Ahn Hyeong Sik HS Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea., Il Min Ahn, and Seon-Heui Lee.
• Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
• Sci Rep. 2015 Jun 29; 5: 11665.

AbstractCopeptin, the C-terminal part of provasopressin, has emerged as a novel prognostic marker after hemorrhagic or ischemic stroke. The aim of this study was to quantitatively assess the prognostic significance of plasma copeptin level on functional outcome and mortality in patients with acute stroke using a meta-analysis of the available evidence. Thirteen relevant studies from 2,746 patients were finally included in our study. An elevated plasma copeptin level was associated with an increased risk of unfavorable outcome and mortality after stroke (OR 1.77; 95% CI, 1.44-2.19 and OR 3.90; 95% CI 3.07-4.95, respectively). The result of the pooled measure on standardized mean difference (SMD) was that plasma copeptin levels were found to be significantly higher in patients who died compared to survivors (SMD 1.70; 95% CI, 1.36-2.03). A stratified analysis by study region showed significant differences in SMD of copeptin, and the heterogeneity among studies was significantly decreased. However, the positive association of copeptin with poor prognosis after stroke was consistent in each stratified analysis. The present meta-analysis suggests that early measurement of plasma copeptin could provide better prognostic information about functional outcome and mortality in patients with acute stroke.

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