• R Sobottke, K Zarghooni, M Krengel, S Delank, H Seifert, G Fätkenheuer, I Ernestus, T Källicke, T Frangen, K Arasteh, M Oette, and P Eysel.
• Department of Orthopaedic Surgery, University of Cologne, Cologne, Germany. rolf.sobottke@uk-koeln.de
• Spine. 2009 Jun 1; 34 (13): E452-8.

Study DesignMulticenter retrospective case series.ObjectiveTo determine relevant clinical presentation and outcome of human immunodeficiency virus (HIV)-positive patients with spondylodiscitis as a function of the treatment.Summary Of Background DataThis is the first study comparing the clinical outcome of HIV-positive patients with spondylodiscitis as a function of the treatment.MethodsWe performed a national multicenter retrospective case series comparing operatively versus conservatively treated HIV-positive patients with spondylodiscitis presenting between 1991 and 2007.ResultsTwenty patients were included in the study. The average age of the patients at the time of admission was 43.0 years. The sex ratio m:w resulted in 2.3:1. On admission, 50% of the patients were in CDC stage C3. The CD4 T-cell count was determined as being 237.5/microL on average. At the occurrence of spondylodiscitis HIV had been known for a mean 8.5 years. In altogether 75% of the cases a pathogen was found. In 3 cases, mixed infections were present. Half of the patients received surgery. In none of these patients a wound infection or a delay of wound healing could be observed. One patient died during in-patient stay. Eleven of the 19 patients could be followed up a mean 13 months after discharge. In the follow-up period further 3 patients died on an average of 45 months after discharge.ConclusionThe occurrence of spondylodiscitis in HIV-positive patients is associated with a low CD4 T-cell count. The probability of mixed infections rises with a CD4 T-cell count <100/microL. The occurrence of spondylodiscitis in HIV-positive patients is accompanied by high mortality. Operative therapy of spondylodiscitis in HIV-positive patients is not associated with an increased surgical complication rate. HIV infection or AIDS should not have an influence on decision-making regarding conservative or operative therapy of spondylodiscitis.

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