• Am J Emerg Med · Aug 2020

    Case Reports

    Serotonin syndrome from sertraline monotherapy: A case report.

    • Kevin M Duignan, Austin M Quinn, and Amy M Matson.
    • Department of Emergency Medicine, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, United States; Frank H. Netter MD School of Medicine, Quinnipiac University, 275 Mt Carmel Ave, Hamden, CT 06518, United States. Electronic address: kevin.duignan@qu.edu.
    • Am J Emerg Med. 2020 Aug 1; 38 (8): 1695.e51695.e61695.e5-1695.e6.

    AbstractSerotonin syndrome (SS) is a rare, potentially life-threatening adverse drug reaction. Selective serotonin reuptake inhibitors (SSRIs) are among a number of pharmaceuticals that all contribute to SS, but SS caused by SSRI monotherapy is rare. We present a case of probable sertraline-induced SS. A 36-year-old male presented to the emergency department four times in one week with a constellation of autonomic and neuromuscular symptoms. He had been taking sertraline at a therapeutic dose for less than three months. Moderate SS was diagnosed using the Hunter criteria during the fourth visit, when it was seen that he had hyperreflexia and inducible ankle clonus. The patient's symptoms resolved within 24 hours with lorazepam, intravenous fluids, and discontinuation of sertraline. In the emergency department it is important to have a high clinical suspicion for SS even if the patient is taking SSRI monotherapy at therapeutic doses.Copyright © 2019 Elsevier Inc. All rights reserved.

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