• Guowei Li, Tolulope T Sajobi, Bijoy K Menon, Lawrence Korngut, Mark Lowerison, Matthew James, Stephen B Wilton, Tyler Williamson, Stephanie Gill, Lauren L Drogos, Eric E Smith, Sunita Vohra, Michael D Hill, Lehana Thabane, and 2016 Symposium on Registry-Based Randomized Controlled Trials in Calgary.
• Department of Clinical Epidemiology & Biostatistics, McMaster University, 1280 Main St W, Hamilton, Ontario L8S 4L8, Canada; St. Joseph's Healthcare Hamilton, McMaster University, 50 Charlton Ave E, Hamilton, Ontario L8N 1Y2, Canada.
• J Clin Epidemiol. 2016 Dec 1; 80: 16-24.

AbstractRegistry-based randomized controlled trials are defined as pragmatic trials that use registries as a platform for case records, data collection, randomization, and follow-up. Recently, the application of registry-based randomized controlled trials has attracted increasing attention in health research to address comparative effectiveness research questions in real-world settings, mainly due to their low cost, enhanced generalizability of findings, rapid consecutive enrollment, and the potential completeness of follow-up for the reference population, when compared with conventional randomized effectiveness trials. However several challenges of registry-based randomized controlled trials have to be taken into consideration, including registry data quality, ethical issues, and methodological challenges. In this article, we summarize the advantages, challenges, and areas for future research related to registry-based randomized controlled trials.Copyright © 2016 Elsevier Inc. All rights reserved.

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