• Amanda Nickles Fader, Abigail Duncan Winder, Samith Sandadi, and Robert Debernardo.
• Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Greater Baltimore Medical Center/Johns Hopkins Hospital, Baltimore, MD, USA. ; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University Hospitals of Cleveland, Seidel Cancer Center, Cleveland, OH, USA.
• J Gynecol Oncol. 2012 Oct 1; 23 (4): 288-90.

AbstractSweet's syndrome, or acute febrile neutrophilic dermatosis, is a condition characterized by fever, neutrophilia, erythematous skin lesions, and a dermal infiltrate consisting predominantly of mature neutrophils on histology. Sweet's syndrome is a reactive phenomenon and should be considered a cutaneous marker of systemic disease, including underlying malignancy. We present a case of a 56-year-old woman who presented with vague abdominal symptoms and a tender, erythematous rash on her extremities. Biopsy of her skin lesions revealed Sweet's syndrome. A work-up for malignancy eventually demonstrated a pelvic mass and carcinomatosis, and a diagnosis of advanced-stage papillary serous ovarian carcinoma was subsequently made. In postmenopausal women who present with Sweet's syndrome, a comprehensive evaluation for malignancy is indicated. In women with a known diagnosis of cancer, Sweet's syndrome may manifest in the detection of persistent or recurrent disease.

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