• Maria C Mondardini, Angela Amigoni, Paolo Cortellazzi, Alessandra Di Palma, Cristina Navarra, Sergio G Picardo, Rosa Puzzutiello, Laura Rinaldi, Francesca Vitale, Geremia Zito Marinosci, and Giorgio Conti.
• Pediatric Intensive Care Unit, Department of Woman's, Child's and Urological Diseases, S. Orsola-Malpighi Polyclinic University Hospital, Bologna, Italy - mariacristina.mondardini@aosp.bo.it.
• Minerva Anestesiol. 2019 Dec 1; 85 (12): 1334-1345.

AbstractIntranasal dexmedetomidine, although still off-label, recently boasted an increasing consensus for different uses, namely, in diagnostic non-painful procedures, in painful procedures and in surgical premedication. However, at present, there is no consensus regarding indications, dosage and timing for administration. This article aims to provide a comprehensive literature analysis and summarize the more recent evidence of research on pediatric intranasal dexmedetomidine, in the effort to better delineate usefulness and limits for each specific indication. In summary, available pediatric evidence confirms efficacy and safety of dexmedetomidine for intranasal administration. Pharmacological profile for the various pediatric ages and procedures still needs quality studies and pharmacokinetic in-depth analysis.

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