• Fredrike Blokzijl, Saskia Houterman, Bart H M van Straten, Edgar Daeter, George J Brandon Bravo Bruinsma, Willem Dieperink, Michiel F Reneman, Frederik Keus, van der Horst Iwan C C ICC Department of Intensive Care, University of Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands., and Massimo A Mariani.
• Department of Cardiothoracic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: f.zwiers-blokzijl@umcg.nl.
• J. Thorac. Cardiovasc. Surg. 2021 Apr 1; 161 (4): 1204-1210.e7.

ObjectivesTo explore the effect of surgical aortic valve replacement on quality of life and the variance with age, particularly in patients at risk of deterioration.MethodsIn an observational, multicenter, cohort study of routinely collected health data, patients undergoing and electively operated between January 2011 and January 2015 with pre- and postoperative quality of life data were included. Patients were classified into 3 age groups: <65, 65-79, and ≥80 years. Quality of life was measured at baseline and at 1-year follow-up using the Short-Form Health Survey-12 or SF-36. We defined a >5-point difference as a minimal clinically important difference. Multivariable linear regression analysis, with adjustment for confounders, was used to evaluate the association between age and quality of life.ResultsIn 899 patients, mean physical health increased from 55 to 66 and mental health from 60 to 66. A minimal clinically important decreased physical health was observed in 12% of patients aged <65 years, 16% of patients aged 65-79 years, and 22% of patients aged ≥80 years (P = .023). A decreased mental health was observed in 15% of patients aged <65 years, 22% of patients aged 65-79 years, and 24% aged ≥80 years (P = .030). Older age and a greater physical and mental score at baseline were associated with a decreased physical and mental quality of life (P < .001).ConclusionsPatients surviving surgical aortic valve replacement on average improve in physical and mental quality of life; nonetheless, with increasing age patients are at higher risk of experiencing a deterioration.Copyright © 2019 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

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