• Ilke Onur Kazaz, Ahmet Mentese, Selim Demir, Gokcen Kerimoglu, Fatih Colak, Akin Bodur, Ahmet Alver, Omer Kutlu, and Suleyman Turedi.
• Department of Urology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
• Am J Emerg Med. 2020 Jan 1; 38 (1): 33-37.

PurposeThe aim of this study was to investigate the effect of berberine (BBR) on oxidative stress in an experimental testicular I/R injury model.MethodsEighteen rats were divided into three groups: control group, torsion-detorsion (T/D) group, and BBR + T/D group. In the pre-treatment of the BBR group, 200 mg/kg BBR was given intraperitoneally 30 min before detorsion. Tissue malondialdehyde (MDA), total oxidant status (TOS), and total antioxidant status (TAS) levels were determined using colorimetric methods. Histological evaluation of the tissue samples was evaluated using hematoxylin-eosin staining.ResultsIn T/D group, tissue MDA, TOS, and oxidative stress index levels were higher than control group. These increases were significantly reversed with BBR pre-treatment. Although Johnsen scores were lower in T/D group than the control group, BBR pre-treatment recovered the Johnsen scores.ConclusionThese results suggest that BBR can inhibit I/R-induced testicular injury by suppressing oxidative stress. Further studies may prove that BBR is a useful agent as an adjunctive treatment in surgical repair in human cases.Copyright © 2019 Elsevier Inc. All rights reserved.

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