Amiodarone-related acute respiratory distress syndrome

Respiration · Jan 2006

Case Reports

Amiodarone-related acute respiratory distress syndrome following sudden withdrawal of steroids.

Acute lung toxicity is a rare but classical complication of amiodarone therapy. We report the case of a patient who developed an optic neuropathy after 15 years of amiodarone administration, and who was treated for 2 weeks with steroids. ⋯ Postmortem lung histologic examination was consistent with amiodarone-induced pneumonitis. Since this complication is thought to be of immunological origin, we speculate that the sudden withdrawal of steroids was implicated in the development of the acute lung injury.

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- Pierre-Emmanuel Charles, Jean-Marc Doise, Quenot Jean-Pierre JP, Géraldine Muller, Hervé Aube, Nicolas Baudouin, Françoise Piard, Jean-François Besancenot, and Bernard Blettery.
- Service de Réanimation Médicale, Dijon University Hospital, Dijon, France. pierre-emmanuel.charles@chu-dijon.fr
- Respiration. 2006 Jan 1; 73 (2): 248-9.
AbstractAcute lung toxicity is a rare but classical complication of amiodarone therapy. We report the case of a patient who developed an optic neuropathy after 15 years of amiodarone administration, and who was treated for 2 weeks with steroids. Following withdrawal of steroids, the patient rapidly developed an acute respiratory distress syndrome. Postmortem lung histologic examination was consistent with amiodarone-induced pneumonitis. Since this complication is thought to be of immunological origin, we speculate that the sudden withdrawal of steroids was implicated in the development of the acute lung injury.

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Amiodarone-related acute respiratory distress syndrome following sudden withdrawal of steroids.

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