• Ilya M Danelich, John R Bergquist, Whitney J Bergquist, Jennifer L Osborn, Sampaguita S Wright, Brittany J Tefft, Ashley W Sturm, Diana R Langworthy, Jay Mandrekar, Richard M Devine, Scott R Kelley, Kellie L Mathis, John H Pemberton, Adam K Jacob, and David W Larson.
• Department of Pharmacy, Mayo Clinic Hospital - Rochester, Rochester, Minnesota.
• Dis. Colon Rectum. 2018 Oct 1; 61 (10): 1187-1195.

BackgroundExcessive perioperative fluid administration likely increases postoperative cardiovascular, infectious, and GI complications. Early administration of diuretics after elective surgery facilitates rapid mobilization of excess fluid, potentially leading to decreased bowel edema, more rapid return of bowel function, and reduced length of hospital stay.ObjectiveThis study aimed to evaluate the benefit of early diuresis after elective colon and rectal surgery in the setting of an enhanced recovery after surgery practice.DesignThis was a prospective study.SettingsThe study was conducted at a quaternary referral center.PatientsA randomized, open-label, parallel-group trial was conducted in patients undergoing elective colon and rectal surgery at a single quaternary referral center.InterventionThe primary intervention was administration of intravenous furosemide plus enhanced recovery after surgery on postoperative day 1 and 2 versus enhanced recovery after surgery alone.Main Outcome MeasuresThe primary outcome was length of hospital stay. Secondary outcomes included 30-day readmission rate, time to stool output during hospitalization after surgery, and incidence of various complications within the first 48 hours of hospital stay.ResultsIn total, 123 patients were randomly assigned to receive either furosemide plus enhanced recovery after surgery (n = 62) or enhanced recovery after surgery alone (n = 61). Groups were evenly matched at baseline. At interim analysis, length of hospital stay was not superior in the intervention group (80.6 vs 99.6 hours, p = 0.564). No significant difference was identified in the rates of nasogastric tube replacement (1.6% vs 9.7%, p = 0.125). Time to return of bowel function was significantly longer in the intervention group (45.4 vs 48.8 hours, p = 0.048). The decision was made to end the study early because the conditional power of the study favored futility.LimitationsThis was a single-center study.ConclusionsEarly administration of furosemide does not significantly reduce the length of hospital stay after elective colon and rectal surgery in the setting of enhanced recovery after surgery practice. See Video Abstract at http://links.lww.com/DCR/A714.

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