• Wei Xu, Chen-Chen Tan, Juan-Juan Zou, Xi-Peng Cao, and Lan Tan.
• Neurology Department, Qingdao Municipal Hospital Group, Qingdao University, Qingdao, Shandong, China 1037219730@qq.com.
• J. Neurol. Neurosurg. Psychiatr. 2020 Mar 1; 91 (3): 236-244.

ObjectivesTo conduct an updated systematic review and meta-analysis of association between sleep and all-cause cognitive disorders.MethodsPubMed and EMBASE were searched from inception to 18 February 2019. Cohort studies exploring longitudinal associations of sleep with cognitive decline or dementia were included. The multivariable-adjusted effect estimates were pooled by random-effects models, with credibility assessment. The robust error meta-regression model was used to conduct the dose-response meta-analysis for sleep duration.Results11 155 reports were searched and 51 eligible cohorts with 15 sleep problems were included for our meta-analyses. Ten types of sleep conditions or parameters, including six (insomnia, fragmentation, daytime dysfunction, prolonged latency, rapid eye movement sleep behaviour disorder and excessive time in bed) with moderate-to-high levels of evidence, were linked to higher risk of all-cause cognitive disorders. Furthermore, a U-shaped relationship was revealed for the associations with sleep duration.ConclusionsSleep management might serve as a promising target for dementia prevention.© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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