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Expert Rev Clin Immunol · Jan 2011
ReviewAcute infusion reactions induced by monoclonal antibody therapy.
- Enrico Maggi, Alessandra Vultaggio, and Andrea Matucci.
- Center for Research, Transfer and High Education DENOTHE, University of Florence, Policlinico di Careggi, Viale Morgagni 85, 50134 Florence, Italy. e.maggi@dmi.unifi.it
- Expert Rev Clin Immunol. 2011 Jan 1; 7 (1): 55-63.
AbstractThis article reports recent evidence on epidemiological data concerning monoclonal antibody (mAb) infusion-related anaphylaxis, as well as recent data on the correlation between mAb immunogenicity and safety profiles. Pathogenic mechanisms of mAb-related adverse reactions including hypersensitivity, IgE- and non-IgE-mediated events and cytokine release syndrome are also highlighted. Finally, the role of serum anti-mAb antibodies as markers to monitor the safety of such therapeutical compounds are extensively evaluated. The anaphylaxis occurring during therapy with the anti-TNF-α mAb infliximab, largely used in immune-mediated diseases, has been taken as a paradigm.
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