• Christoph Baumgartner and Ekaterina Pataraia.
• Department of Clinical Neurology, Medical University of Vienna, Währinger Gurtel 18-20, A-1090 Vienna, Austria. christoph.baumgartner@meduniwien.ac.at
• Curr. Opin. Neurol. 2006 Apr 1; 19 (2): 181-6.

Purpose Of ReviewThis review considers the current role of magnetoencephalography in clinical epileptology.Recent FindingsWhile magnetoencephalography and electroencephalography complement each other for interictal spike detection, magnetoencephalography is more sensitive in neocortical epilepsy. In temporal lobe epilepsy, magnetoencephalography can attribute epileptic activity to subcompartments of the temporal lobe and differentiate between patients with mesial, lateral and diffuse seizure onsets. In extratemporal epilepsy, magnetoencephalography provides unique information in nonlesional cases and helps to define the relationship of epileptic activity with respect to lesions and eloquent cortex. Magnetoencephalography also contributes to the clinical decision process in patients with cortical dysplasias, Landau-Kleffner syndrome and recurrent seizures after prior epilepsy surgery. Magnetoencephalography-guided re-evaluation of magnetic resonance imaging helps to reveal previously unrecognized lesions. In a presurgical setting interictal magnetoencephalography was superior to scalp electroencephalography. Complete resection of the magnetoencephalography-defined irritative zone has prognostic implications on postoperative seizure control. Magnetoencephalography can reliably localize sensorimotor and language cortex. Disadvantages of this technique include the difficulties in obtaining ictal recordings and the considerable costs involved.SummaryMagnetoencephalography has been developed to a valuable noninvasive tool in clinical epileptology. The development of approaches which take into account both magnetoencephalography and electroencephalography simultaneously should provide more useful information in the future.

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