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- V Das Gupta and A R Heble.
- J Pharm Sci. 1984 Nov 1; 73 (11): 1553-6.
AbstractA high-performance liquid chromatographic (HPLC) method has been developed for the quantitation of acetaminophen, chlorpheniramine maleate, dextromethorphan hydrobromide, and phenylpropanolamine hydrochloride in combination in pharmaceutical dosage forms using a single column and three different mobile phases. The method developed is sensitive for the content uniformity test for tablets. No preliminary extraction procedure is required for liquid preparation and a very simple extraction procedure is required for tablets. The method is accurate and precise with RSD (based on five injections) of 1.2, 2.4, 1.9, and 1.6% for acetaminophen, chlorpheniramine, dextromethorphan, and phenylpropanolamine, respectively.
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