• J. Cardiothorac. Vasc. Anesth. · Apr 2020

    Fifty Percent Effective Dose of Intranasal Dexmedetomidine Sedation for Transthoracic Echocardiography in Children With Cyanotic and Acyanotic Congenital Heart Disease.

    • Fei Yang, Shangyingying Li, Yuan Shi, Lu Liu, Mao Ye, Jin Zhang, Hui Liu, Feng Liu, Qing Yu, Mang Sun, Qin Tian, and Shengfen Tu.
    • Department of Anesthesiology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation base of Child development and Critical Disorders; Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
    • J. Cardiothorac. Vasc. Anesth. 2020 Apr 1; 34 (4): 966-971.

    ObjectivesTo determine the 50% and 95% effective dose of intranasal dexmedetomidine sedation for transthoracic echocardiography in children with cyanotic and acyanotic congenital heart disease.DesignA prospective, nonrandomized study.SettingA tertiary care teaching hospital.ParticipantsPatients younger than 18 months with known or suspected congenital heart disease scheduled for transthoracic echocardiography with sedation.InterventionsPatients were divided into a cyanotic group (blood oxygen saturation <85%) or an acyanotic group (blood oxygen saturation ≥85%). This study used Dixon's up-and-down method sequential allocation design. In both groups, the initial dose of intranasal dexmedetomidine was 2 μg/kg and the gradient of increase or decrease was 0.25 μg/kg.Measurements And Main ResultsThe 50% effective dose (95% confidence interval) of intranasal dexmedetomidine sedation for transthoracic echocardiography was 3.2 (2.78-3.55) μg/kg and 1.9 (1.69-2.06) μg/kg in the cyanotic and acyanotic groups, respectively. None of the patients experienced significant adverse events.ConclusionThe 50% (95% confidence intervals) effective doses of intranasal dexmedetomidine sedation for transthoracic echocardiography were 3.2 (2.78-3.55) μg/kg and 1.9 (1.69-2.06) μg/kg in children with cyanotic and acyanotic congenital heart disease, respectively.Copyright © 2019 Elsevier Inc. All rights reserved.

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