• Iyuki Namekata, Shogo Hamaguchi, Yumi Wakasugi, Minato Ohhara, Yoshitaka Hirota, and Hikaru Tanaka.
• Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Funabashi, Chiba 274-8510, Japan. iyuki@phar.toho-u.ac.jp
• Eur. J. Pharmacol. 2013 Apr 15; 706 (1-3): 48-55.

AbstractThe effects of sarco-endoplasmic reticulum Ca(2+)-ATPase (SERCA) activators, ellagic acid and gingerol, on the contraction and Ca(2+) transient were examined in isolated myocardia from streptozotocin-induced diabetic mice and compared with control mice. The time required for relaxation of the right ventricular free wall was significantly longer in streptozotocin-treated mice. The basal Ca(2+) concentration of isolated ventricular myocytes from streptozotocin-treated mice was significantly higher than those from control mice. The Ca(2+) transient decay rate was significantly lower in myocytes from streptozotocin-treated mice. Cyclopiazonic acid, a SERCA inhibitor, decreased the rate of relaxation and the rate of Ca(2+) transient decay; these effects were larger in control mice. Both ellagic acid and gingerol accelerated the rate of relaxation and the rate of Ca(2+) transient decay; these effects were larger in the streptozotocin-treated mice. The acceleration of relaxation by ellagic acid and gingerol was completely inhibited by cyclopiazonic acid. These results suggest that the diabetes mellitus-induced myocardial diastolic dysfunction is partly caused by reduction of SERCA function and can be ameliorated by SERCA activators.Copyright © 2013 Elsevier B.V. All rights reserved.

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