• ShuYing Fu, WenDong Lin, XiNing Zhao, ShengJin Ge, and ZhangGang Xue.
• Department of Anesthesia, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
• Biomed Res Int. 2018 Jan 1; 2018: 9491750.

BackgroundNeuromuscular blockade is a risk factor for postoperative respiratory weakness during the immediate postoperative period. The quantitative relationships between postoperative pulmonary-function impairment and residual neuromuscular blockade are unknown.Methods113 patients who underwent elective laparoscopic cholecystectomy were enrolled in this study. They all had a pulmonary-function test (PFT) during the preoperative evaluation. Predictive values based on demographic data were also recorded. The train-of-four ratio (TOFR) was recorded at the same time as the PFT and at every 5 minutes in the qualified 98 patients in the postanesthesia care unit (PACU). We analyzed the degree of PFT recovery when the TOFR had recovered to different degrees.ResultsThere was a significant difference (P < 0.05) between the preoperative baseline value and the postoperative forced vital capacity at each TOFR point, except at a TOFR value of 1.1. There was also a significant difference (P < 0.05) between the preoperative baseline value and the postoperative peak expiratory flow at each TOFR point.ConclusionsPostoperative residual neuromuscular blockade was common (75.51%) after tracheal extubation, and pulmonary function could not recover to an acceptable level (85% of baseline value), even if TOFR had recovered to 0.90.Trial RegistrationChinese Clinical Trial Register is ChiCTR-OOC-15005838.

11 keywords...

hide…